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Wei-Wen Kuo Selected Research

Insulin-Like Growth Factor II (Somatomedin A)

12/2021Leu27 IGF-II-induced hypertrophy in H9c2 cardiomyoblasts is ameliorated by saffron by regulation of calcineurin/NFAT and CaMKIIδ signaling.
10/2020Danshen (Salvia miltiorhiza) inhibits Leu27 IGF-II-induced hypertrophy in H9c2 cells.
1/2018Rab9-dependent autophagy is required for the IGF-IIR triggering mitophagy to eliminate damaged mitochondria.
10/2017Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy.
11/2015CREB Negatively Regulates IGF2R Gene Expression and Downstream Pathways to Inhibit Hypoxia-Induced H9c2 Cardiomyoblast Cell Death.
6/2015NFIL3 suppresses hypoxia-induced apoptotic cell death by targeting the insulin-like growth factor 2 receptor.
2/2015Prolactin protects cardiomyocytes against intermittent hypoxia-induced cell damage by the modulation of signaling pathways related to cardiac hypertrophy and proliferation.
6/2009Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through G(alpha)q and downstream calcineurin signaling in myocardial cells.
8/2008IGF-II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells.
5/2008IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Galphaq interaction and protein kinase C-alpha/CaMKII activation in H9c2 cardiomyoblast cells.
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Wei-Wen Kuo Research Topics

Disease

40Hypertrophy
02/2022 - 11/2004
39Cardiomegaly (Heart Hypertrophy)
02/2022 - 11/2004
31Neoplasms (Cancer)
02/2022 - 07/2006
28Fibrosis (Cirrhosis)
08/2022 - 10/2005
22Hypoxia (Hypoxemia)
10/2021 - 03/2007
18Hypertension (High Blood Pressure)
09/2022 - 01/2004
15Inflammation (Inflammations)
04/2022 - 05/2006
14Heart Failure
01/2022 - 05/2006
13Cardiomyopathies (Cardiomyopathy)
09/2021 - 10/2010
11Hepatocellular Carcinoma (Hepatoma)
01/2022 - 10/2006
10Hyperglycemia
08/2022 - 04/2012
10Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 10/2009
9Diabetic Cardiomyopathies
12/2021 - 01/2011
9Heart Diseases (Heart Disease)
01/2021 - 10/2005
9Colonic Neoplasms (Colon Cancer)
01/2018 - 04/2006
9Neoplasm Metastasis (Metastasis)
01/2018 - 09/2006
8Cardiotoxicity
02/2022 - 09/2016
7Wounds and Injuries (Trauma)
01/2022 - 01/2016
7Mitochondrial Diseases (Mitochondrial Disease)
12/2021 - 02/2015
7Body Weight (Weight, Body)
09/2021 - 02/2003
7Colorectal Neoplasms (Colorectal Cancer)
05/2020 - 04/2006
6Myocardial Infarction
06/2019 - 05/2008
6Obesity
01/2019 - 10/2007
4Diabetes Mellitus
01/2021 - 09/2015
4Carcinogenesis
12/2019 - 11/2014
4Hyperlipidemias (Hyperlipidemia)
01/2019 - 01/2016
3Rheumatoid Arthritis
10/2022 - 05/2006
3Hyperplasia
01/2022 - 04/2021
3Parkinson Disease (Parkinson's Disease)
06/2020 - 11/2010
3Osteosarcoma (Osteogenic Sarcoma)
05/2020 - 04/2005

Drug/Important Bio-Agent (IBA)

47Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2005
15Angiotensin IIIBA
09/2022 - 07/2006
14CalcineurinIBA
02/2022 - 12/2005
14Insulin-Like Growth Factor II (Somatomedin A)IBA
12/2021 - 07/2006
11Estrogen ReceptorsIBA
10/2020 - 07/2006
11Atrial Natriuretic Factor (ANF)IBA
10/2019 - 11/2004
10Reactive Oxygen Species (Oxygen Radicals)IBA
12/2021 - 04/2012
10Insulin-Like Growth Factor I (IGF-1)IBA
02/2015 - 09/2005
8CollagenIBA
10/2022 - 01/2011
8Doxorubicin (Adriamycin)FDA LinkGeneric
01/2022 - 09/2016
8Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA
01/2022 - 05/2008
8Pharmaceutical PreparationsIBA
01/2022 - 07/2014
8Insulin-Like PeptidesIBA
10/2021 - 05/2006
8Glucose (Dextrose)FDA LinkGeneric
10/2021 - 09/2013
8Streptozocin (Streptozotocin)FDA Link
09/2021 - 10/2010
8Matrix Metalloproteinases (MMPs)IBA
06/2019 - 05/2006
7IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)IBA
12/2021 - 07/2006
7Phosphotransferases (Kinase)IBA
12/2021 - 05/2009
7Estrogens (Estrogen)FDA Link
01/2018 - 09/2006
5Advanced Glycation End ProductsIBA
08/2022 - 08/2018
5Mitogen-Activated Protein KinasesIBA
02/2022 - 04/2005
5Sirtuin 1IBA
01/2022 - 01/2018
5Hematoxylin (Haematoxylon)IBA
01/2022 - 10/2007
5Eosine Yellowish-(YS) (Eosin)IBA
01/2022 - 10/2007
5Transcription Factors (Transcription Factor)IBA
01/2021 - 06/2008
5CateninsIBA
09/2019 - 08/2011
5Brain Natriuretic Peptide (Natrecor)FDA Link
01/2019 - 05/2008
4Protein Kinases (Protein Kinase)IBA
02/2022 - 04/2005
4Histone Deacetylase InhibitorsIBA
01/2022 - 01/2014
4Insulin-Like Growth Factor Binding Protein 3IBA
10/2021 - 01/2015
4diallyl trisulfideIBA
10/2021 - 02/2013
4TeaIBA
02/2021 - 03/2014
4Protein Phosphatase 1IBA
11/2020 - 04/2017
4Galactose (Galactopyranose)FDA LinkGeneric
01/2020 - 03/2016
4transcription factor NF-AT c3IBA
11/2019 - 01/2015
4Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
06/2019 - 05/2009
4Plasminogen Activators (Plasminogen Activator)IBA
06/2019 - 05/2009
4CholesterolIBA
11/2017 - 09/2009
4Apoptosis Regulatory ProteinsIBA
01/2017 - 04/2008
4Tobacco Smoke Pollution (Passive Smoking)IBA
09/2016 - 10/2005
4Transforming Growth Factor beta (TGF-beta)IBA
05/2016 - 11/2004
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2016 - 03/2007
4LipidsIBA
10/2015 - 04/2006
4Death Domain ReceptorsIBA
09/2009 - 10/2005
3epigallocatechin gallate (epigallocatechin-3-gallate)IBA
10/2022 - 11/2017
3Arecoline (Arecolin)IBA
02/2022 - 04/2013
3galanginIBA
01/2022 - 12/2017
3CalciumIBA
12/2021 - 07/2016
3Toll-Like Receptor 4IBA
09/2021 - 06/2013
3rhodamine-phalloidinIBA
07/2021 - 05/2008
3ResveratrolIBA
01/2021 - 01/2018
3AntioxidantsIBA
01/2021 - 09/2013
3Therapeutic UsesIBA
01/2021 - 02/2013
3MicroRNAs (MicroRNA)IBA
11/2020 - 01/2018
3Somatomedin Receptors (Somatomedin Receptor)IBA
01/2020 - 11/2016
3Protein Isoforms (Isoforms)IBA
12/2019 - 12/2016
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2019 - 12/2005
3Tissue Plasminogen Activator (Alteplase)FDA Link
06/2019 - 05/2009
3Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
06/2019 - 06/2013
3NADPH Oxidases (NAD(P)H oxidase)IBA
01/2018 - 09/2013
3Estrogen Receptor alphaIBA
01/2018 - 09/2006
3oxidized low density lipoproteinIBA
11/2017 - 10/2009
3p38 Mitogen-Activated Protein KinasesIBA
08/2017 - 03/2007
3EnzymesIBA
04/2017 - 05/2009
3thymoquinoneIBA
02/2017 - 02/2015
3Dinoprostone (PGE2)FDA Link
02/2017 - 08/2011

Therapy/Procedure

18Therapeutics
10/2022 - 04/2006
6Oral Administration
07/2021 - 06/2013
5Drug Therapy (Chemotherapy)
01/2021 - 07/2014
4Transplantation
01/2022 - 11/2017